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Vitamin deficiency and being underweight can affect the effectiveness of your immune system. For instance, if you do not get enough vitamin D your body won't be able to metabolize calcium and you can get a disease like rickets. If you do not get enough vitamin C you can get scurvy. If you do not get enough iron you get anemia. Nutrition is very important to your immune system and even if you are only have minor deficiencies you can suffer from illnesses that won't go away and from fatigue. You should avoid being undernourished and underweight by using weight gain supplements or calorie supplements.